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DUOS interactie studie docetaxel-prednison: publicatie

De DUOS interactiestudie docetaxel-prednison werd in november 2017 gesloten. De resultaten zijn nu gepubliceerd in ‘British Journal of Clinical Pharmacology’ Effects of prednisone on docetaxel pharmacokinetics in men with metastatic prostate cancer: A randomized drug-drug interaction study.

Conclusion: No significant difference in docetaxel concentrations was observed. In addition, we found similar toxicity profiles in absence and presence of prednisone. Therefore, from a pharmacokinetic point of view, docetaxel may be administrated with or without prednisone.

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